10,11-dihydro-5H-dibenzo(a,d)cycloheptene → HCID 59770425, compound

HRID 2218677Notes

Reaction equation

HRID 2218677 reaction equation
[F:1][C:2]1[C:9]([O:10][CH3:11])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[CH2:12]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13]1>>[F:1][C:2]1[C:9]([O:10][CH3:11])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[C:20]1[C:19]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH2:13][CH2:12][C:26]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]1=2

Participants

3

Reactant 2

HCID 7002910,11-dihydro-5H-dibenzo(a,d)cyclohepteneHCID 37744632-Fluoro-3-methoxybenzaldehyde

Product 1

HCID 59770425HCID 59770425, compoundYield 29.5%

Procedure

Following procedures essentially as described in Example 28 and using 2-fluoro-3-methoxybenzaldehyde (2.4 g, 15.4 mmol) and dibenzosuberane (3.0 g, 15.4 mmol), provides 1.5 g of title compound as white crystals. mp 148.9° C. HPLC shows 96% purity.

Sources & evidence

ORD record
ord-cf71ab69cd8a4684a42143b18755c728
Source dataset
uspto-grants-2008_08
Patent number
US07411072B2

Reaction notes

Loading…