4-(Trifluoromethyl)phenylboronic acid → HCID 68937781, compound

HRID 2218690Notes

Reaction equation

HRID 2218690 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1.Br[CH:15]=[C:16]1[C:22]2[CH:23]=[CH:24][C:25]([Cl:27])=[CH:26][C:21]=2[CH2:20][CH2:19][C:18]2[CH:28]=[CH:29][CH:30]=[CH:31][C:17]1=2>>[Cl:27][C:25]1[CH:24]=[CH:23][C:22]2[C:16](=[CH:15][C:6]3[CH:7]=[CH:8][C:3]([C:2]([F:13])([F:12])[F:1])=[CH:4][CH:5]=3)[C:17]3[CH:31]=[CH:30][CH:29]=[CH:28][C:18]=3[CH2:19][CH2:20][C:21]=2[CH:26]=1

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 688868195-bromomethylene-2-chloro-10,11-dihydro-5H-dibenzo[a,d]cycloheptene

Product 1

HCID 68937781HCID 68937781, compound

Procedure

Following procedures essentially as described in Example 219, below, and using 4-(trifluoromethyl)phenylboronic acid (114 mg, 0.60 mmol) and 5-bromomethylene-2-chloro-10,11-dihydro-5H-dibenzo[a,d]cycloheptene (156 mg, 0.48 mmol) provides the title compound. GC/MS data: retention times in minutes (MS data for M+.ion): 18.52 (384), 18.78(384)Mass Spec (EI+) 384.

Sources & evidence

ORD record
ord-f68440935eff4408a036fed409533ff6
Source dataset
uspto-grants-2008_08
Patent number
US07411072B2

Reaction notes

Loading…