Hydrochloric Acid → HCID 69219680, compound

Participants

Reaction Steps

To trans-(2-{4-[2-(3,3,5,5-Tetramethylcyclohexyl)phenyl]piperazin-1-ylmethyl}cyclopropyl)acetonitrile (8 mg) produced in Example (94a) dissolved in dichloromethane was added a 4N solution of hydrogen chloride in ethyl acetate. Nitrogen was then blown to the solution to remove the solvent. Diethyl ether was added to the obtained residue to produce a solid, which was then triturated by sonication. The supernatant diethyl ether solution was removed and the resulting solid residue was dried by blowing nitrogen, to give 8 mg of the title compound as a light brown solid.

Provenance & Evidence