Hydrochloric Acid → HCID 69219680, compound

HRID 2218877Notes

Reaction equation

HRID 2218877 reaction equation
[CH3:1][C:2]1([CH3:29])[CH2:7][C:6]([CH3:9])([CH3:8])[CH2:5][CH:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[N:16]2[CH2:21][CH2:20][N:19]([CH2:22][C@@H:23]3[CH2:25][C@H:24]3[CH2:26][C:27]#[N:28])[CH2:18][CH2:17]2)[CH2:3]1.[ClH:30]>ClCCl.C(OCC)(=O)C>[ClH:30].[CH3:1][C:2]1([CH3:29])[CH2:7][C:6]([CH3:8])([CH3:9])[CH2:5][CH:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[N:16]2[CH2:21][CH2:20][N:19]([CH2:22][C@@H:23]3[CH2:25][C@H:24]3[CH2:26][C:27]#[N:28])[CH2:18][CH2:17]2)[CH2:3]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59769389trans-(2-{4-[2-(3,3,5,5-Tetramethylcyclohexyl)phenyl]piperazin-1-ylmethyl}cyclopropyl)acetonitrile

Product 1

HCID 69219680HCID 69219680, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8857Ethyl AcetateSolvent

Procedure

To trans-(2-{4-[2-(3,3,5,5-Tetramethylcyclohexyl)phenyl]piperazin-1-ylmethyl}cyclopropyl)acetonitrile (8 mg) produced in Example (94a) dissolved in dichloromethane was added a 4N solution of hydrogen chloride in ethyl acetate. Nitrogen was then blown to the solution to remove the solvent. Diethyl ether was added to the obtained residue to produce a solid, which was then triturated by sonication. The supernatant diethyl ether solution was removed and the resulting solid residue was dried by blowing nitrogen, to give 8 mg of the title compound as a light brown solid.

Workup

  1. customto remove the solvent
  2. additionDiethyl ether was added to the obtained residue
  3. customto produce a solid, which
  4. customwas then triturated by sonication
  5. customThe supernatant diethyl ether solution was removed
  6. customthe resulting solid residue was dried

Sources & evidence

ORD record
ord-dfd3328a394a4bd094e3172e81ed9514
Source dataset
uspto-grants-2008_08
Patent number
US07410971B2

Reaction notes

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