Methyl 2-[(tert-butylamino)sulfonyl]-6-nitrobenzoate → HCID 22024121, compound

HRID 2218942Notes

Reaction equation

HRID 2218942 reaction equation
C([NH:5][S:6]([C:9]1[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-:21])=[O:20])[C:10]=1[C:11]([O:13][CH3:14])=[O:12])(=[O:8])=[O:7])(C)(C)C>FC(F)(F)C(O)=O>[NH2:5][S:6]([C:9]1[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-:21])=[O:20])[C:10]=1[C:11]([O:13][CH3:14])=[O:12])(=[O:8])=[O:7]

Participants

3

Reactant 1

HCID 22024122Methyl 2-[(tert-butylamino)sulfonyl]-6-nitrobenzoate

Product 1

HCID 22024121HCID 22024121, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

300 mg (0.948 mmol) of methyl 2-[(tert-butylamino)sulfonyl]-6-nitrobenzoate in 8 ml of trifluoroacetic acid are stirred at room temperature for 4 h. The mixture is subsequently concentrated to dryness under reduced pressure and the residue is digested with diethyl ether. After filtration with suction and drying, 230 mg (93% of theory) of methyl 2-(aminosulfonyl)-6-nitrobenzoate of m.p. 227-229° C. remain.

Workup

  1. concentrationThe mixture is subsequently concentrated to dryness under reduced pressure
  2. filtrationAfter filtration with suction
  3. customdrying

Sources & evidence

ORD record
ord-6a5f4dc530294305b58a48e33f1e715a
Source dataset
uspto-grants-2008_08
Patent number
US07414011B2

Reaction notes

Loading…