反应详情

To a solution of biphenyl-3,4-diamine (0.99 mmol) in THF:MeOH:water (5 mL:10 mL:10 mL) was added cyanogen bromide (5M solution in acetonitrile, 1.06 mmol). The resulting mixture was stirred at room temperature overnight. The reaction was partitioned between EtOAc and aqueous sodium hydroxide and the aqueous layer re-extracted with EtOAc. The combined EtOAc extracts were washed with water, brine, dried over MgSO2, then concentrated in vacuo to afford 7 (147 mg, 71%) as an off-white solid.

1. customThe reaction was partitioned between EtOAc and aqueous sodium hydroxide
2. extractionthe aqueous layer re-extracted with EtOAc
3. washThe combined EtOAc extracts were washed with water, brine
4. dry with materialdried over MgSO2
5. concentrationconcentrated in vacuo