反应详情

To a solution of the product of Example 12 (150 mg) and benzylamine (0.062 mL) in DCM (5 mL) was added acetic acid (0.03 mL) and sodium triacetoxyborohydride (165 mg). After 16 h the reaction was treated with 1 N NaOH (20 mL) and extracted with DCM (3×20 mL). The organic layers were dried (Na2SO4), concentrated, and chromatographed (2-3% 2 M methanolic ammonia-DCM) to give the title compound as an oil (150 mg).

1. extractionextracted with DCM (3×20 mL)
2. dry with materialThe organic layers were dried (Na2SO4)
3. concentrationconcentrated
4. customchromatographed (2-3% 2 M methanolic ammonia-DCM)