Hydrochloric Acid → HCID 87761177, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 120 mg of (S)-3-tert-butoxycarbonylamino-7,8-difluoro-4-oxo-5-(2,2,2-trifluoro-ethyl)-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine-1-carboxylic acid 2,2,2-trifluoro-ethyl ester in 4 ml of dioxane was treated with 0.27 ml of hydrochlorid acid (37%). The reaction mixture was warmed to 50° C. for 3 hours. For the working-up, the mixture was evaporated under reduced pressure. The oily residue was evaporated three times with 25 ml of toluene to yield thereby quantitatively the title compound as a light yellow solid which was engaged in the next step without further purification; MS (m/e): 340 (M+H)+.

Provenance & Evidence