Hydrochloric Acid → HCID 87761177, compound

HRID 2219016Notes

Reaction equation

HRID 2219016 reaction equation
[F:1][C:2]([F:35])([F:34])[CH2:3][O:4][C:5]([N:7]1[CH2:13][C@H:12]([NH:14]C(OC(C)(C)C)=O)[C:11](=[O:22])[N:10](CC(F)(F)F)[C:9]2[CH:28]=[C:29]([F:33])[C:30]([F:32])=[CH:31][C:8]1=2)=[O:6].[ClH:36]>O1CCOCC1>[ClH:36].[F:34][C:2]([F:1])([F:35])[CH2:3][O:4][C:5]([N:7]1[CH2:13][C@H:12]([NH2:14])[C:11](=[O:22])[NH:10][C:9]2[CH:28]=[C:29]([F:33])[C:30]([F:32])=[CH:31][C:8]1=2)=[O:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59718691HCID 59718691, compound

Product 1

HCID 87761177HCID 87761177, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
50 °C

Procedure

A solution of 120 mg of (S)-3-tert-butoxycarbonylamino-7,8-difluoro-4-oxo-5-(2,2,2-trifluoro-ethyl)-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine-1-carboxylic acid 2,2,2-trifluoro-ethyl ester in 4 ml of dioxane was treated with 0.27 ml of hydrochlorid acid (37%). The reaction mixture was warmed to 50° C. for 3 hours. For the working-up, the mixture was evaporated under reduced pressure. The oily residue was evaporated three times with 25 ml of toluene to yield thereby quantitatively the title compound as a light yellow solid which was engaged in the next step without further purification; MS (m/e): 340 (M+H)+.

Workup

  1. customthe mixture was evaporated under reduced pressure
  2. customThe oily residue was evaporated three times with 25 ml of toluene
  3. customto yield
  4. customquantitatively the title compound as a light yellow solid which was engaged in the next step without further purification

Sources & evidence

ORD record
ord-3e5206a0e7f94a3f8170cd725e3b2ca4
Source dataset
uspto-grants-2008_08
Patent number
US07414049B2

Reaction notes

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