Hydrochloric Acid → HCID 68974555, compound

HRID 2219019Notes

Reaction equation

HRID 2219019 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:14][N:13]([CH2:15][C:16]([F:19])([F:18])[F:17])[C:12]2[CH:20]=[CH:21][C:22]([F:24])=[CH:23][C:11]=2[NH:10][C:9]1=[O:25])(C)(C)C.[ClH:27]>O1CCOCC1>[ClH:27].[NH2:7][C@@H:8]1[C:9](=[O:25])[NH:10][C:11]2[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:12]=2[N:13]([CH2:15][C:16]([F:19])([F:18])[F:17])[CH2:14]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59718692HCID 59718692, compound

Product 1

HCID 68974555HCID 68974555, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In an analogous procedure to that described in Example 1d), the treatment of the [(S)-7-fluoro-4-oxo-1-(2,2,2-trifluoro-ethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester with hydrochlorid acid (37%) in dioxane yielded the title compound as a light brown foam; MS (m/e): 278 (M+H)+.

Sources & evidence

ORD record
ord-15c5366b4daf4e6d92485d9fbcaa9fef
Source dataset
uspto-grants-2008_08
Patent number
US07414049B2

Reaction notes

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