Hydrochloric Acid → HCID 69271710, compound

HRID 2219026Notes

Reaction equation

HRID 2219026 reaction equation
C(OC(=O)[NH:7][C@@H:8]1[C:14](=[O:15])[N:13]([CH2:16][C:17]([F:20])([F:19])[F:18])[C:12]2[CH:21]=[CH:22][CH:23]=[CH:24][C:11]=2[N:10]([CH2:25][CH2:26][O:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:9]1)(C)(C)C.[ClH:36]>O1CCOCC1>[ClH:36].[NH2:7][C@@H:8]1[C:14](=[O:15])[N:13]([CH2:16][C:17]([F:19])([F:18])[F:20])[C:12]2[CH:21]=[CH:22][CH:23]=[CH:24][C:11]=2[N:10]([CH2:25][CH2:26][O:27][CH2:28][C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59718708HCID 59718708, compound

Product 1

HCID 69271710HCID 69271710, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In an analogous manner to that described in Example 1d), the treatment of the [(S)-5-(2-benzyloxy-ethyl)-2-oxo-1-(2,2,2-trifluoro-ethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester with hydrochlorid acid (37%) in dioxane yielded the title compound as a light yellow foam; MS (m/e): 394 (M+H)+.

Sources & evidence

ORD record
ord-5b8ab515d97e40248f321fa75073b7a2
Source dataset
uspto-grants-2008_08
Patent number
US07414049B2

Reaction notes

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