Hydrochloric Acid → HCID 69269052, compound

HRID 2219034Notes

Reaction equation

HRID 2219034 reaction equation
[F:1][C:2]([F:38])([F:37])[CH2:3][O:4][C:5]([N:7]1[CH2:13][CH:12]([NH:14]C(OC(C)(C)C)=O)[C:11](=[O:22])[N:10]([CH2:23][CH2:24][O:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:9]2[CH:33]=[CH:34][CH:35]=[CH:36][C:8]1=2)=[O:6].[ClH:39]>O1CCOCC1>[ClH:39].[F:38][C:2]([F:1])([F:37])[CH2:3][O:4][C:5]([N:7]1[CH2:13][C@H:12]([NH2:14])[C:11](=[O:22])[N:10]([CH2:23][CH2:24][O:25][CH2:26][C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[C:9]2[CH:33]=[CH:34][CH:35]=[CH:36][C:8]1=2)=[O:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59718673HCID 59718673, compound

Product 1

HCID 69269052HCID 69269052, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In an analogous manner to that described in Example 1d), the treatment of the (RS)-5-(2-benzyloxy-ethyl)-3-tert-butoxycarbonylamino-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine-1-carboxylic acid 2,2,2-trifluoro-ethyl ester with hydrochlorid acid (37%) in dioxane yielded quantitatively the title compound as a light yellow foam; MS (m/e): 438 (M+H)+.

Sources & evidence

ORD record
ord-f80bb41fabac4f8bacf79c9d223bce44
Source dataset
uspto-grants-2008_08
Patent number
US07414049B2

Reaction notes

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