Hydrochloric Acid → HCID 87641429, compound

HRID 2219035Notes

Reaction equation

HRID 2219035 reaction equation
[F:1][C:2]([F:37])([F:36])[CH2:3][CH2:4][CH2:5][O:6][C:7]([N:9]1[CH2:15][C@H:14]([NH:16]C(OC(C)(C)C)=O)[C:13](=[O:24])[N:12]([CH2:25][CH2:26][CH2:27][C:28]([F:31])([F:30])[F:29])[C:11]2[CH:32]=[CH:33][CH:34]=[CH:35][C:10]1=2)=[O:8].[ClH:38]>O1CCOCC1>[ClH:38].[F:37][C:2]([F:1])([F:36])[CH2:3][CH2:4][CH2:5][O:6][C:7]([N:9]1[CH2:15][C@H:14]([NH2:16])[C:13](=[O:24])[N:12]([CH2:25][CH2:26][CH2:27][C:28]([F:30])([F:31])[F:29])[C:11]2[CH:32]=[CH:33][CH:34]=[CH:35][C:10]1=2)=[O:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 87761721HCID 87761721, compound

Product 1

HCID 87641429HCID 87641429, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In an analogous manner to that described in Example 1d), the treatment of the (S)-3-tert-butoxycarbonylamino-4-oxo-5-(4,4,4-trifluoro-butyl)-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine-1-carboxylic acid 4,4,4-trifluoro-butyl ester with hydrochlorid acid (37%) in dioxane yielded quantitatively the title compound as a white foam; MS (m/e): 442 (M+H)+.

Sources & evidence

ORD record
ord-92a7efda0e12491792595b2a4b5c9888
Source dataset
uspto-grants-2008_08
Patent number
US07414049B2

Reaction notes

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