反应详情

Tert-butyl benzyloxy(4-cyanobutyl)carbamate was dissolved in a solution of 4 M HCl in 1,4-dioxane and the mixture was stirred for 18 h at room temperature. The solvent was removed under reduced pressure and the residue was treated with ethyl acetate and diethyl ether. A solid formed which was washed with diethyl ether, filtered and dried under high vacuum to give 1-(benzyloxy)piperidin-2-imine hydrochloride as a pale yellow solid.

1. customThe solvent was removed under reduced pressure
2. additionthe residue was treated with ethyl acetate and diethyl ether
3. customA solid formed which
4. washwas washed with diethyl ether
5. filtrationfiltered
6. customdried under high vacuum