4-(2-(Pyrrolidin-1-yl)ethoxy)aniline → HCID 178419007, compound

HRID 2219169Notes

Reaction equation

HRID 2219169 reaction equation
[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:16][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[NH:22][C:21](=[O:26])[C:20]2=[CH:27]O>>[Cl:16][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[NH:22][C:21](=[O:26])[C:20]2=[CH:27][NH:15][C:12]1[CH:11]=[CH:10][C:9]([O:8][CH2:7][CH2:6][N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 64937494-(2-(Pyrrolidin-1-yl)ethoxy)anilineHCID 1784190365-chloro-3-(hydroxymethylidene)-1H-indol-2-one

Product 1

HCID 178419007HCID 178419007, compoundYield 79%

Procedure

In a manner similar to that described in Example 231, 4-(2-Pyrrolidin-1-yl-ethoxy)-phenylamine (632 mg, 1.2 equiv.) and 5-chloro-3-hydroxymethylene-1,3-dihydro-indol-2-one (500 mg, 2.56 mmol, 1 equiv.) are reacted to give the named compound as a yellow solid (775 mg, 79%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-6d1434cc3da244afbf8c4a78657fcc4e
Source dataset
uspto-grants-2008_08
Patent number
US07414054B2

Reaction notes

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