反应详情

A 5N NaOH solution (0.937 mL) is added slowly to a stirred suspension of 1-chloro-isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide hydrochloride (1.51 g, 4.69 mmol) in THF (20 mL)/CH3OH (20 mL) at ambient temperature to form a clear solution. After concentration in vacuo, the tan solid is suspended in EtOAc/CH3OH and sonicated for a few minutes. The mixture is filtered and concentrated to give 1.21 g (4.23 mmol, 90% yield) of the title compound as a tan powder. ESIMS: m/z 286 [(M+H)+, 35Cl], 288 [(M+H)+, 37Cl].

1. customto form a clear solution
2. concentrationAfter concentration in vacuo
3. customsonicated for a few minutes
4. filtrationThe mixture is filtered
5. concentrationconcentrated