Aluminium lithium hydride → HCID 69551927, compound

HRID 2219212Notes

Reaction equation

HRID 2219212 reaction equation
[H-].[H-].[H-].[H-].[Li+].[Al+3].[CH2:7]([C:14]1[CH:44]=[CH:43][CH:42]=[CH:41][C:15]=1[O:16][CH2:17][CH2:18][CH2:19][N:20]([CH2:38][C:39]#[N:40])[CH:21]([C:30]1[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=1)[C:22]1[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[CH2:7]([C:14]1[CH:44]=[CH:43][CH:42]=[CH:41][C:15]=1[O:16][CH2:17][CH2:18][CH2:19][N:20]([CH:21]([C:22]1[CH:23]=[CH:24][C:25]([O:28][CH3:29])=[CH:26][CH:27]=1)[C:30]1[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=1)[CH2:38][CH2:39][NH2:40])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 86610928HCID 86610928, compound

Product 1

HCID 69551927HCID 69551927, compoundYield 85%

Procedure

By following similar procedure as described in Preparation 95, LiAlH4 reduction of {[3-(2-benzyl-phenoxy)-propyl]-[bis-(4-methoxy-phenyl)-methyl]-amino}-acetonitrile gives the title compound (85% yield) as oil. ESIMS: m/z 511 (M+H)+.

Sources & evidence

ORD record
ord-fdda02ffdc8d4f3d8a7610e6093c70c2
Source dataset
uspto-grants-2008_08
Patent number
US07414063B2

Reaction notes

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