Sodium Hydroxide → HCID 178511378, compound

HRID 2219215Notes

Reaction equation

HRID 2219215 reaction equation
[OH-].[Na+:2].[ClH:3].[NH2:4][CH2:5][CH2:6][NH:7][S:8]([C:11]1[C:12]2[CH:13]=[CH:14][N:15]=[C:16]([OH:21])[C:17]=2[CH:18]=[CH:19][CH:20]=1)(=[O:10])=[O:9]>CO>[Cl-:3].[Na+:2].[NH2:4][CH2:5][CH2:6][NH:7][S:8]([C:11]1[C:12]2[CH:13]=[CH:14][N:15]=[C:16]([OH:21])[C:17]=2[CH:18]=[CH:19][CH:20]=1)(=[O:9])=[O:10]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178479235HCID 178479235, compound

Product 1

HCID 178511378HCID 178511378, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A 1N NaOH solution (5.96 mL) is added slowly to a stirred suspension of 1-hydroxy-isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide hydrochloride (1.81 g, 5.96 mmol) in CH3OH (10 mL) at ambient temperature under nitrogen. The resultant mixture is allowed to stir for 30 minutes. The mixture is then concentrated at 50° C. under vacuum to give a 1.87 g of the title compound (96% yield) as a white powder.

Workup

  1. concentrationThe mixture is then concentrated at 50° C. under vacuum

Sources & evidence

ORD record
ord-b831fdf4fac443849df0aa32ff969088
Source dataset
uspto-grants-2008_08
Patent number
US07414063B2

Reaction notes

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