Water → HCID 58816127, compound

HRID 2219235Notes

Reaction equation

HRID 2219235 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][CH2:10][NH:11][CH2:12][CH2:13][NH:14][S:15]([C:18]2[C:19]3[CH:20]=[CH:21][N:22]=[CH:23][C:24]=3[CH:25]=[CH:26][CH:27]=2)(=[O:17])=[O:16])=[CH:4][CH:3]=1.[OH:28]OS([O-])=O.[K+].[OH2:34]>CO>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:9][CH2:10][NH:11][CH2:12][CH2:13][NH:14][S:15]([C:18]2[C:19]3[CH:20]=[CH:21][N:22]=[CH:23][C:24]=3[CH:25]=[CH:26][CH:27]=2)(=[O:16])=[O:17])(=[O:28])=[O:34])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 23707502Potassium hydroxy sulfiteHCID 58816151HCID 58816151, compound

Product 1

HCID 58816127HCID 58816127, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A stirred mixture of isoquinoline-5-sulfonic acid {2-[2-(4-bromo-phenylsulfanyl)-ethylamino]-ethyl}-amide (73.0 mg, 0.157 mmol) and oxone (289 mg, 0.470 mmol) in CH3OH (5 mL)/H2O (1.3 mL) is allowed to stir at ambient temperature for 30 minutes to form a suspension. After filtration, the white solid is sonicated in H2O (10 mL), then filtered to give a tan solid of the title compound. ESIMS: m/z 498 [(M+H)+, 79Br], 500 [(M+H)+, 81Br].

Workup

  1. customto form a suspension
  2. filtrationAfter filtration
  3. customthe white solid is sonicated in H2O (10 mL)
  4. filtrationfiltered

Sources & evidence

ORD record
ord-d8e8897ae5254ca3bf28d3ec2378b3ad
Source dataset
uspto-grants-2008_08
Patent number
US07414063B2

Reaction notes

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