4-Chloroaniline → HCID 68880662, compound

HRID 2219269Notes

Reaction equation

HRID 2219269 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.Cl[CH2:10][C:11]1[N:15]([CH3:16])[N:14]=[N:13][N:12]=1>>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][CH2:10][C:11]2[N:15]([CH3:16])[N:14]=[N:13][N:12]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 78124-ChloroanilineHCID 122050865-(chloromethyl)-1-methyl-1H-1,2,3,4-tetrazole

Product 1

HCID 68880662HCID 68880662, compoundYield 36.3%

Procedure

The same procedure as step 2 of example 1 was accomplished except for using p-chloroaniline (5.8 g, 45.3 mmol) and 5-chloromethyl-1-methyl-1H-tetrazol (6 g, 45.3 mmol). The crude product was purified by silica gel column chromatography (developing solvent-n-hexane:ethyl acetate=2:1), to give desired compound (3.68 g, yield: 36%).

Workup

  1. customThe crude product was purified by silica gel column chromatography (developing solvent-n-hexane:ethyl acetate=2:1)

Sources & evidence

ORD record
ord-e1b51ef173634852817c3cb3d00faa62
Source dataset
uspto-grants-2008_08
Patent number
US07414068B2

Reaction notes

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