HCID 11097971, compound → HCID 69216536, compound

HRID 2219282Notes

Reaction equation

HRID 2219282 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][C@:11]([CH3:18])([CH:13]([O:16][CH3:17])[O:14][CH3:15])[C@@H:10]3[O:19][C@@H:9]3[C:8]=2[CH:20]=1)([O-:3])=[O:2].[CH2:21]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[NH:29][CH2:30][C:31]1[N:32]=[N:33][N:34]([CH3:36])[N:35]=1)[CH3:22]>>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][C@:11]([CH3:18])([CH:13]([O:16][CH3:17])[O:14][CH3:15])[C@H:10]([OH:19])[C@@H:9]([N:29]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[CH2:21][CH3:22])[CH2:30][C:31]3[N:32]=[N:33][N:34]([CH3:36])[N:35]=3)[C:8]=2[CH:20]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 11097971HCID 11097971, compoundHCID 45095277HCID 45095277, compound

Product 1

HCID 69216536HCID 69216536, compoundYield 22%

Procedure

The same procedure as step 3 of example 1 was accomplished, except for using the epoxide compound (270 mg, 0.98 mmol) obtained in step 1 of example 2 and N-(2-ethylphenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl)amine. The crude product was purified by silica gel column chromatography (developing solvent-n-hexane:ethyl acetate=1:2), to give desired compound (100 mg, yield: 22%).

Workup

  1. customThe crude product was purified by silica gel column chromatography (developing solvent-n-hexane:ethyl acetate=1:2)

Sources & evidence

ORD record
ord-eb3acc1750f8465ea4d1a59e16700a29
Source dataset
uspto-grants-2008_08
Patent number
US07414068B2

Reaction notes

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