HCID 11097971, compound → HCID 68882519, compound

HRID 2219283Notes

Reaction equation

HRID 2219283 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][C@:11]([CH3:18])([CH:13]([O:16][CH3:17])[O:14][CH3:15])[C@@H:10]3[O:19][C@@H:9]3[C:8]=2[CH:20]=1)([O-:3])=[O:2].[CH3:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]([O:30][CH3:31])=[O:29])=[CH:24][C:23]=1[NH:32][CH2:33][C:34]1[N:35]=[N:36][N:37]([CH3:39])[N:38]=1>>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][C@:11]([CH3:18])([CH:13]([O:16][CH3:17])[O:14][CH3:15])[C@H:10]([OH:19])[C@@H:9]([N:32]([C:23]3[CH:24]=[C:25]([C:28]([O:30][CH3:31])=[O:29])[CH:26]=[CH:27][C:22]=3[CH3:21])[CH2:33][C:34]3[N:35]=[N:36][N:37]([CH3:39])[N:38]=3)[C:8]=2[CH:20]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 11097971HCID 11097971, compoundHCID 68883256HCID 68883256, compound

Product 1

HCID 68882519HCID 68882519, compoundYield 51%

Procedure

The same procedure as step 3 of example 1 was accomplished, except for using the epoxide compound (420 mg, 1.48 mmol) obtained in step 1 of example 2 and N-(2-methyl-5-(methoxycarbonyl)phenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl)amine. The crude product was purified by silica gel column chromatography (developing solvent-n-hexane:ethyl acetate=1:2), to give desired compound (520 mg, yield: 51%).

Workup

  1. customThe crude product was purified by silica gel column chromatography (developing solvent-n-hexane:ethyl acetate=1:2)

Sources & evidence

ORD record
ord-ffab5686f26045b4bcdc1b4f968808f8
Source dataset
uspto-grants-2008_08
Patent number
US07414068B2

Reaction notes

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