4-(Methylthio)phenylboronic acid → HCID 67421064, compound

HRID 2219320Notes

Reaction equation

HRID 2219320 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1.[CH3:18][S:19][C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1>>[CH3:11][C:10]1[O:9][N:8]=[C:7]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:6]=1[C:4]1[N:3]=[CH:2][N:1]([C:23]2[CH:24]=[CH:25][C:20]([S:19][CH3:18])=[CH:21][CH:22]=2)[CH:5]=1

Participants

3

Reactant 2

HCID 27339594-(Methylthio)phenylboronic acidHCID 178434980HCID 178434980, compound

Product 1

HCID 67421064HCID 67421064, compoundYield 45%

Procedure

As described for Example 3, 4-(1H-imidazol-4-yl)-5-methyl-3-phenyl-isoxazole (112.6 mg, 0.5 mmol) was converted, using 4-methylthiophenylboronic acid instead of 4-fluorophenylboronic acid, to the title compound (78 mg, 45%) which was obtained as a white solid. MS (ESI): m/e=348.0 [M+H]+.

Sources & evidence

ORD record
ord-c9ce726aa28b49889b18b8ea579b25b4
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

Loading…