2-Chloropyrimidine → HCID 23726019, compound

HRID 2219343Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]3[N:14]=[CH:15][NH:16][CH:17]=3)=[C:11]([CH3:18])[O:10][N:9]=2)=[CH:4][CH:3]=1.Cl[C:20]1[N:25]=[CH:24][CH:23]=[CH:22][N:21]=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]3[N:14]=[CH:15][N:16]([C:20]4[N:25]=[CH:24][CH:23]=[CH:22][N:21]=4)[CH:17]=3)=[C:11]([CH3:18])[O:10][N:9]=2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 744042-Chloropyrimidine

HCID 178434973HCID 178434973, compound

Product 1

HCID 23726019HCID 23726019, compoundYield 73%

Procedure

As described for Example 49, 3-(4-bromo-phenyl)-4-(1H-imidazol-4-yl)-5-methyl-isoxazole (61 mg, 0.2 mmol) using 2-chloropyrimidine instead of 4-fluoroacetophenone was converted to the title compound (56 mg, 73%) which was obtained as a light yellow solid. MS: m/e=382.0/384.1 [M+H]+.

Sources & evidence

ORD record: ord-baadb35e64fb4768ae2fcd8e3969a70e
Source dataset: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07414061B2

Reaction notes

Loading…