Benzene, 1-fluoro-4-(trifluoromethyl)- → HCID 23725751, compound

HRID 2219345Notes

Reaction equation

HRID 2219345 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:13]([C:14]3[N:15]=[CH:16][NH:17][CH:18]=3)=[C:12]([CH3:19])[O:11][N:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].F[C:21]1[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][CH:22]=1>>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:13]([C:14]3[N:15]=[CH:16][N:17]([C:21]4[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][CH:22]=4)[CH:18]=3)=[C:12]([CH3:19])[O:11][N:10]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

3

Reactant 2

HCID 67873Benzene, 1-fluoro-4-(trifluoromethyl)-HCID 178435006HCID 178435006, compound

Product 1

HCID 23725751HCID 23725751, compoundYield 10%

Procedure

As described for Example 53, 3-(3,4-difluoro-phenyl)-4-(1H-imidazol-4-yl)-5-methyl-isoxazole (78 mg, 0.3 mmol) using 4-fluorobenzotrifluoride instead of 4-fluoroacetophenone was converted to the title compound (12 mg, 10%) which was obtained as a colourless gum. MS: m/e=406.3 [M+H]+.

Sources & evidence

ORD record
ord-442a4dd8b30647f7924ab0990610c2b9
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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