p-Fluoronitrobenzene → HCID 23725484, compound

HRID 2219347Notes

Reaction equation

HRID 2219347 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]1[N:14]=[C:15]([CH3:18])[NH:16][CH:17]=1.F[C:20]1[CH:25]=[CH:24][C:23]([N+:26]([O-:28])=[O:27])=[CH:22][CH:21]=1>>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:3]=1[C:13]1[N:14]=[C:15]([CH3:18])[N:16]([C:20]2[CH:25]=[CH:24][C:23]([N+:26]([O-:28])=[O:27])=[CH:22][CH:21]=2)[CH:17]=1

Participants

3

Reactant 2

HCID 9590p-FluoronitrobenzeneHCID 178432460HCID 178432460, compound

Product 1

HCID 23725484HCID 23725484, compoundYield 36%

Procedure

As described for Example 57, 5-methyl-4-(2-methyl-1H-imidazol-4-yl)-3-phenyl-isoxazole (70 mg, 0.3 mmol) using 1-fluoro-4-nitrobenzene instead of 4-fluoroacetophenone was converted to the title compound (38 mg, 36%) which was obtained as an off-white solid. MS: m/e=361.4 [M+H]+.

Sources & evidence

ORD record
ord-f862f3b9de514e99be8631c3bd1d9277
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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