3-(Chloromethyl)-5-methyl-1,2-oxazole → HCID 23725695, compound

HRID 2219356Notes

Reaction equation

HRID 2219356 reaction equation
[CH2:1]([O:8][CH2:9][C:10]1[NH:11][CH:12]=[C:13]([C:15]2[C:16]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[N:17][O:18][C:19]=2[CH3:20])[N:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:28][C:29]1[CH:33]=[C:32]([CH3:34])[O:31][N:30]=1>>[CH2:1]([O:8][CH2:9][C:10]1[N:11]([CH2:28][C:29]2[CH:33]=[C:32]([CH3:34])[O:31][N:30]=2)[CH:12]=[C:13]([C:15]2[C:16]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[N:17][O:18][C:19]=2[CH3:20])[N:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 27357633-(Chloromethyl)-5-methyl-1,2-oxazoleHCID 178434979HCID 178434979, compound

Product 1

HCID 23725695HCID 23725695, compoundYield 63%

Procedure

As described for Example 67, 4-(2-benzyloxymethyl-1H-imidazol-4-yl)-5-methyl-3-phenyl-isoxazole (100 mg, 0.29 mmol) using 3-(chloromethyl)-5-methylisoxazole instead of benzyl bromide was converted to the title compound (80 mg, 63%) which was obtained as a light yellow gum. MS: m/e=441.4 [M+H]+.

Sources & evidence

ORD record
ord-f35c47b05f304ac1b38539c20d76e167
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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