N-(3-Aminopropyl)morpholine → HCID 67420675, compound

HRID 2219363Notes

Reaction equation

HRID 2219363 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]1[N:14]=[CH:15][N:16]([C:18]2[CH:26]=[CH:25][C:21]([C:22]([OH:24])=O)=[CH:20][CH:19]=2)[CH:17]=1.[N:27]1([CH2:33][CH2:34][CH2:35][NH2:36])[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1>>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:3]=1[C:13]1[N:14]=[CH:15][N:16]([C:18]2[CH:26]=[CH:25][C:21]([C:22]([NH:36][CH2:35][CH2:34][CH2:33][N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)=[O:24])=[CH:20][CH:19]=2)[CH:17]=1

Participants

3

Reactant 2

HCID 61055N-(3-Aminopropyl)morpholineHCID 67420918HCID 67420918, compound

Product 1

HCID 67420675HCID 67420675, compoundYield 10%

Procedure

As described for Example 71c, 4-[4-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazol-1-yl]-benzoic acid (100 mg, 0.29 mmol) was converted, using 3-morpholin-4-yl-propylamine instead of cyclopropylmethylamine, to the title compound (13 mg, 10%) which was obtained as an off-white solid. MS: m/e=472.0 [M+H]+.

Sources & evidence

ORD record
ord-5dc60fc168ce4f31b67ac3168d32ba48
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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