Cyclobutylamine → HCID 67419999, compound

HRID 2219374Notes

Reaction equation

[CH:1]1([NH2:5])[CH2:4][CH2:3][CH2:2]1.[CH3:6][C:7]1[O:11][N:10]=[C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]=1[C:18]1[N:19]=[CH:20][N:21]([C:23]2[CH:24]=[C:25]([CH:29]=[CH:30][CH:31]=2)[C:26](O)=[O:27])[CH:22]=1>>[CH:1]1([NH:5][C:26](=[O:27])[C:25]2[CH:29]=[CH:30][CH:31]=[C:23]([N:21]3[CH:22]=[C:18]([C:8]4[C:9]([C:12]5[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=5)=[N:10][O:11][C:7]=4[CH3:6])[N:19]=[CH:20]3)[CH:24]=2)[CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 75645Cyclobutylamine

HCID 67421094HCID 67421094, compound

Product 1

HCID 67419999HCID 67419999, compoundYield 45%

Procedure

As described for Example 71, cyclobutylamine was converted, using 3-[4-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazol-1-yl]-benzoic acid (100 mg, 0.29 mmol) instead of 4-[4-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazol-1-yl]-benzoic acid, to the title compound (52 mg, 45%) which was obtained as an off-white solid. MS: m/e=399.1 [M+H]+.

Sources & evidence

ORD record: ord-10908a2c9b0e40d4a44d32941a639775
Source dataset: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07414061B2

Reaction notes

Loading…