Cyclobutylamine → HCID 67420858, compound

HRID 2219386Notes

Reaction equation

HRID 2219386 reaction equation
[CH:1]1([NH2:5])[CH2:4][CH2:3][CH2:2]1.[F:6][C:7]1[CH:8]=[C:9]([C:13]2[C:17]([C:18]3[N:19]=[CH:20][N:21]([C:23]4[CH:24]=[C:25]([CH:29]=[CH:30][CH:31]=4)[C:26](O)=[O:27])[CH:22]=3)=[C:16]([CH3:32])[O:15][N:14]=2)[CH:10]=[CH:11][CH:12]=1>>[CH:1]1([NH:5][C:26](=[O:27])[C:25]2[CH:29]=[CH:30][CH:31]=[C:23]([N:21]3[CH:22]=[C:18]([C:17]4[C:13]([C:9]5[CH:10]=[CH:11][CH:12]=[C:7]([F:6])[CH:8]=5)=[N:14][O:15][C:16]=4[CH3:32])[N:19]=[CH:20]3)[CH:24]=2)[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 75645CyclobutylamineHCID 67421104HCID 67421104, compound

Product 1

HCID 67420858HCID 67420858, compoundYield 38%

Procedure

As described for Example 71c, cyclobutylamine was converted, using 3-{4-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-yl]-imidazol-1-yl}-benzoic acid (100 mg, 0.28 mmol) instead of 4-[4-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazol-1-yl]-benzoic acid, to the title compound (44 mg, 38%) which was obtained as an off-white solid. MS: m/e=417.0 [M+H]+.

Sources & evidence

ORD record
ord-4c71cace4046425c93a376eb10ed81df
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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