Benzene, 1-fluoro-4-(trifluoromethyl)- → HCID 23725805, compound

HRID 2219401Notes

Reaction equation

HRID 2219401 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][CH:3]=1.[CH2:12]([C:14]1[O:18][N:17]=[C:16]([C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)[C:15]=1[C:26]1[N:27]=[CH:28][NH:29][CH:30]=1)[CH3:13]>>[CH2:12]([C:14]1[O:18][N:17]=[C:16]([C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)[C:15]=1[C:26]1[N:27]=[CH:28][N:29]([C:2]2[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][CH:3]=2)[CH:30]=1)[CH3:13]

Participants

3

Reactant 2

HCID 67873Benzene, 1-fluoro-4-(trifluoromethyl)-HCID 178438222HCID 178438222, compound

Product 1

HCID 23725805HCID 23725805, compoundYield 33%

Procedure

As described for 1f, 1-fluoro-4-trifluoromethyl-benzene was converted, using 5-ethyl-3-(4-fluoro-phenyl)-4-(1H-imidazole-4-yl)-isoxazole (100 mg, 0.39 mmol) instead of 4-(1H-imidazol-4-yl)-3-phenyl-isoxazole was converted to the title compound (52 mg, 33%) which was obtained as an off-white solid. MS: m/e=402.1 [M+H]+.

Sources & evidence

ORD record
ord-3f421af8cef24f8596e87da7367cb02d
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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