Methyl 4-methoxyacetoacetate → HCID 67420638, compound

HRID 2219408Notes

Reaction equation

[OH:1]/[N:2]=[C:3](\Cl)/[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:11][O:12][C:13](=[O:20])[CH2:14][C:15](=O)[CH2:16][O:17][CH3:18]>>[CH3:11][O:12][C:13]([C:14]1[C:3]([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)=[N:2][O:1][C:15]=1[CH2:16][O:17][CH3:18])=[O:20]

Participants

Reactant 2

HCID 123500Methyl 4-methoxyacetoacetate

HCID 5706359Alpha-chlorobenzaldoxime

Product 1

HCID 67420638HCID 67420638, compound

Procedure

As described for Example 36c, (E)- and/or (Z)-N-hydroxy-benzenecarboximidoyl chloride (14.04 g, 90 mmol) was converted, using 4-methoxy-3-oxo-butyric acid methyl ester instead of acteylacetone to the crude title compound (18.76 g) which was obtained as an off-white solid and used directly in the next step without further purification.

Sources & evidence

ORD record: ord-17851a5b2f5a44b1a06242f6a64200cd
Source dataset: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07414061B2

Reaction notes

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