Thionyl Chloride → HCID 87392931, compound

HRID 2219409Notes

Reaction equation

HRID 2219409 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[O:8][N:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]=1[C:15]([OH:17])=O.S(Cl)([Cl:20])=O>>[CH3:1][O:2][CH2:3][C:4]1[O:8][N:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]=1[C:15]([Cl:20])=[O:17]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 67420628HCID 67420628, compound

Product 1

HCID 87392931HCID 87392931, compoundYield 100%

Conditions

Temperature
60 °C

Procedure

A suspension of 5-methoxymethyl-3-phenyl-isoxazole-4-carboxylic acid (10.0 g, 43.0 mmol) in thionyl chloride (20 mL) was heated at 60° C. for 3 h. The resulting mixture was concentrated under reduced pressure to afford the crude title compound (11.16 g, 100%) which was obtained as a light yellow liquid. The crude product was directly used in the next step without further purification.

Workup

  1. concentrationThe resulting mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d719638afc3f460abdb7c48d16e1a637
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

Loading…