Methyl 4-methoxyacetoacetate → HCID 45117070, compound

HRID 2219416Notes

Reaction equation

HRID 2219416 reaction equation
[OH:1]/[N:2]=[C:3](\Cl)/[C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][CH:5]=1.[CH3:12][O:13][C:14](=[O:21])[CH2:15][C:16](=O)[CH2:17][O:18][CH3:19]>>[CH3:12][O:13][C:14]([C:15]1[C:3]([C:4]2[CH:9]=[CH:8][C:7]([F:10])=[CH:6][CH:5]=2)=[N:2][O:1][C:16]=1[CH2:17][O:18][CH3:19])=[O:21]

Participants

3

Reactant 2

HCID 123500Methyl 4-methoxyacetoacetateHCID 57063604-Fluoro-N-hydroxybenzimidoyl chloride

Product 1

HCID 45117070HCID 45117070, compoundYield 74%

Procedure

As described for Example 36c, (E)- and/or (Z)-N-hydroxy-4-fluoro-benzenecarboximidoyl chloride (12.1 g, 70 mmol) was converted, using 4-methoxy-3-oxo-butyric acid methyl ester instead of acetylacetone to the title compound (13.8 g, 74%) which was obtained as a light yellow solid. MS: m/e=266.0 [M+H]+.

Sources & evidence

ORD record
ord-3776d238d9fb4b8b952e6dc0922ac95e
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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