Benzene, 1-fluoro-4-(trifluoromethyl)- → 3-(4-fluoro-phenyl)-5-methoxymethyl-4-[1-(4-trifluoromethyl-phenyl)-1H-imidazol-4-yl]-isoxazole

HRID 2219420Notes

Reaction equation

HRID 2219420 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]3[N:14]=[CH:15][NH:16][CH:17]=3)=[C:11]([CH2:18][O:19][CH3:20])[O:10][N:9]=2)=[CH:4][CH:3]=1.F[C:22]1[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]3[N:14]=[CH:15][N:16]([C:22]4[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=4)[CH:17]=3)=[C:11]([CH2:18][O:19][CH3:20])[O:10][N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 67873Benzene, 1-fluoro-4-(trifluoromethyl)-HCID 1784947533-(4-fluoro-phenyl)-4-(1H-imidazol-4-yl)-5-methoxymethyl-isoxazole

Product 1

HCID 237258553-(4-fluoro-phenyl)-5-methoxymethyl-4-[1-(4-trifluoromethyl-phenyl)-1H-imidazol-4-yl]-isoxazoleYield 57%

Procedure

As described for Example 142f, 3-(4-fluoro-phenyl)-4-(1H-imidazol-4-yl)-5-methoxymethyl-isoxazole (546 mg, 2.0 mmol) was converted, using 1-fluoro-4-trifluoromethylbenzene instead of 1-(4-fluorophenyl)-ethanone, to the title compound (520 mg, 57%) which was obtained as light yellow solid. MS: m/e=418.4[M+H]+.

Sources & evidence

ORD record
ord-81e07a7e8c2c47e6998d28c26ef95f86
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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