HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene, 1-fluoro-4-(trifluoromethyl)- → 3-(4-fluoro-phenyl)-5-methoxymethyl-4-[1-(4-trifluoromethyl-phenyl)-1H-imidazol-4-yl]-isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene, 1-fluoro-4-(trifluoromethyl)- | HCID 67873 | — |
| Reactant | 3-(4-fluoro-phenyl)-4-(1H-imidazol-4-yl)-5-methoxymethyl-isoxazole | HCID 178494753 | — |
| Product | 3-(4-fluoro-phenyl)-5-methoxymethyl-4-[1-(4-trifluoromethyl-phenyl)-1H-imidazol-4-yl]-isoxazole | HCID 23725855 | 57% |
Reaction Steps
As described for Example 142f, 3-(4-fluoro-phenyl)-4-(1H-imidazol-4-yl)-5-methoxymethyl-isoxazole (546 mg, 2.0 mmol) was converted, using 1-fluoro-4-trifluoromethylbenzene instead of 1-(4-fluorophenyl)-ethanone, to the title compound (520 mg, 57%) which was obtained as light yellow solid. MS: m/e=418.4[M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07414061B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-81e07a7e8c2c47e6998d28c26ef95f86 |
| Source note | uspto-grants-2008_08 |