Sodium ethoxide → HCID 67420517, compound

HRID 2219426Notes

Reaction equation

HRID 2219426 reaction equation
Cl[CH2:2][C:3]1[N:4]([C:20]2[CH:25]=[CH:24][C:23]([N+:26]([O-:28])=[O:27])=[CH:22][CH:21]=2)[CH:5]=[C:6]([C:8]2[C:9]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[N:10][O:11][C:12]=2[CH3:13])[N:7]=1.[O-:29][CH2:30][CH3:31].[Na+]>C(O)C.CO>[CH2:30]([O:29][CH2:2][C:3]1[N:4]([C:20]2[CH:25]=[CH:24][C:23]([N+:26]([O-:28])=[O:27])=[CH:22][CH:21]=2)[CH:5]=[C:6]([C:8]2[C:9]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[N:10][O:11][C:12]=2[CH3:13])[N:7]=1)[CH3:31]

Participants

5

Reactant 2

HCID 2723922Sodium ethoxideHCID 23725534HCID 23725534, compound

Product 1

HCID 67420517HCID 67420517, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

As described for Example 150, 4-[2-chloromethyl-1-(4-nitro-phenyl)-1H-imidazol-4-yl]-5-methyl-3-phenyl-isoxazole (50 mg, 0.13 mmol), using sodium ethoxide in ethanol instead of sodium methoxide in methanol, was converted to the title compound (47 mg, 92%) which was obtained as a yellow solid. MS: m/e=405.5 [M+H]+.

Sources & evidence

ORD record
ord-739701e883774f63804b2f7e461a5342
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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