4-Bromobenzyl alcohol → HCID 23725588, compound

HRID 2219431Notes

Reaction equation

HRID 2219431 reaction equation
Cl[CH2:2][C:3]1[N:4]([C:20]2[CH:25]=[CH:24][C:23]([N+:26]([O-:28])=[O:27])=[CH:22][CH:21]=2)[CH:5]=[C:6]([C:8]2[C:9]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[N:10][O:11][C:12]=2[CH3:13])[N:7]=1.[Br:29][C:30]1[CH:37]=[CH:36][C:33]([CH2:34][OH:35])=[CH:32][CH:31]=1>>[Br:29][C:30]1[CH:37]=[CH:36][C:33]([CH2:34][O:35][CH2:2][C:3]2[N:4]([C:20]3[CH:25]=[CH:24][C:23]([N+:26]([O-:28])=[O:27])=[CH:22][CH:21]=3)[CH:5]=[C:6]([C:8]3[C:9]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)=[N:10][O:11][C:12]=3[CH3:13])[N:7]=2)=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 701194-Bromobenzyl alcoholHCID 23725534HCID 23725534, compound

Product 1

HCID 23725588HCID 23725588, compoundYield 15%

Procedure

As described for Example 153, 4-[2-chloromethyl-1-(4-nitro-phenyl)-1H-imidazol-4-yl]-5-methyl-3-phenyl-isoxazole (100 mg, 0.25 mmol), using 4-bromobenzyl alcohol instead of 4-methylbenzyl alcohol, was converted to the title compound (21 mg, 15%) which was obtained as a light yellow solid. MS: m/e=545.3/547.3 [M+H]+.

Sources & evidence

ORD record
ord-cf080bb055f349a3910b51407e6fd790
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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