2-Methyl-1,3-thiazol-4-amine → 6-Methyl-3-(2-methyl-2H-pyrazol-3-ylamino)-pyridine-2-carboxylic acid (2-methyl-thiazol-4-yl)-amide

HRID 2219559Notes

Reaction equation

HRID 2219559 reaction equation
C(O[C:4]([C:6]1[C:11]([NH:12][C:13]2[N:14]([CH3:18])[N:15]=[CH:16][CH:17]=2)=[CH:10][CH:9]=[C:8]([CH3:19])[N:7]=1)=[O:5])C.[NH2:20][C:21]1[N:22]=[C:23]([CH3:26])[S:24][CH:25]=1>>[CH3:26][C:23]1[S:24][CH:25]=[C:21]([NH:20][C:4]([C:6]2[C:11]([NH:12][C:13]3[N:14]([CH3:18])[N:15]=[CH:16][CH:17]=3)=[CH:10][CH:9]=[C:8]([CH3:19])[N:7]=2)=[O:5])[N:22]=1

Participants

3

Reactant 2

HCID 147727002-Methyl-1,3-thiazol-4-amineHCID 692372996-Methyl-3-(2-methyl-2H-pyrazol-3-ylamino)-pyridine-2-carboxylic acid ethyl ester

Product 1

HCID 115879366-Methyl-3-(2-methyl-2H-pyrazol-3-ylamino)-pyridine-2-carboxylic acid (2-methyl-thiazol-4-yl)-amide

Procedure

The title compound, was prepared from 6-Methyl-3-(2-methyl-2H-pyrazol-3-ylamino)-pyridine-2-carboxylic acid ethyl ester in accordance with the general method of example 75, step 2 using 4-Amino-2-methylthiazole instead of 3-Amino-1-methyl-pyrazole to yield the final compound as a light brown solid, MS (ISP): m/e=329.1 (M+H+).

Sources & evidence

ORD record
ord-d1c072b7d00d4a21bdd9df8cdb167405
Source dataset
uspto-grants-2008_08
Patent number
US07414060B2

Reaction notes

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