2-Methyl-1,3-thiazol-4-amine → 3-(2,5-Dimethyl-2H-pyrazol-3-ylamino)-6-methyl-pyridine-2-carboxylic acid (2-methyl-thiazol-4-yl)-amide

HRID 2219565Notes

Reaction equation

HRID 2219565 reaction equation
C(O[C:4]([C:6]1[C:11]([NH:12][C:13]2[N:14]([CH3:19])[N:15]=[C:16]([CH3:18])[CH:17]=2)=[CH:10][CH:9]=[C:8]([CH3:20])[N:7]=1)=[O:5])C.[NH2:21][C:22]1[N:23]=[C:24]([CH3:27])[S:25][CH:26]=1>>[CH3:27][C:24]1[S:25][CH:26]=[C:22]([NH:21][C:4]([C:6]2[C:11]([NH:12][C:13]3[N:14]([CH3:19])[N:15]=[C:16]([CH3:18])[CH:17]=3)=[CH:10][CH:9]=[C:8]([CH3:20])[N:7]=2)=[O:5])[N:23]=1

Participants

3

Reactant 2

HCID 147727002-Methyl-1,3-thiazol-4-amineHCID 692364173-(2,5-Dimethyl-2H-pyrazol-3-ylamino)-6-methyl-pyridine-2-carboxylic acid ethyl ester

Product 1

HCID 116025913-(2,5-Dimethyl-2H-pyrazol-3-ylamino)-6-methyl-pyridine-2-carboxylic acid (2-methyl-thiazol-4-yl)-amide

Procedure

The title compound, was prepared from 3-(2,5-Dimethyl-2H-pyrazol-3-ylamino)-6-methyl-pyridine-2-carboxylic acid ethyl ester and 4-Amino-2-methylthiazole in accordance with the general method of Example 78, step 2 to yield the final compound as a light-yellow solid, MS (ISP): m/e=343.0 (M+H+).

Sources & evidence

ORD record
ord-a274873efb654f5fbccceb08f7987873
Source dataset
uspto-grants-2008_08
Patent number
US07414060B2

Reaction notes

Loading…