5-Bromopyrimidine → 6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide

HRID 2219583Notes

Reaction equation

HRID 2219583 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH:7][C:8]([C:10]2[C:15]([NH2:16])=[CH:14][CH:13]=[C:12]([CH:17]3[CH2:19][CH2:18]3)[N:11]=2)=[O:9])=[N:3]1.Br[C:21]1[CH:22]=[N:23][CH:24]=[N:25][CH:26]=1>>[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH:7][C:8]([C:10]2[C:15]([NH:16][C:21]3[CH:22]=[N:23][CH:24]=[N:25][CH:26]=3)=[CH:14][CH:13]=[C:12]([CH:17]3[CH2:19][CH2:18]3)[N:11]=2)=[O:9])=[N:3]1

Participants

3

Reactant 2

HCID 783445-BromopyrimidineHCID 866075993-Amino-6-cyclopropyl-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide

Product 1

HCID 117097816-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide

Procedure

The title compound, was prepared from 3-Amino-6-cyclopropyl-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide and 5-bromopyrimidine in accordance with the general method of example 4 using to yield the final compound as a yellow crystalline solid, MS (ISP): m/e=336.1 (M+H+).

Sources & evidence

ORD record
ord-3ef88952e9ab4672beff5c072cf42740
Source dataset
uspto-grants-2008_08
Patent number
US07414060B2

Reaction notes

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