Pyrimidin-5-amine → HCID 58368048, compound

HRID 2219590Notes

Reaction equation

HRID 2219590 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:11](Br)=[CH:10][CH:9]=[C:8]([CH:13]2[CH2:15]C2)[N:7]=1)=[O:5])[CH3:2].[NH2:16][C:17]1[CH:18]=[N:19][CH:20]=[N:21][CH:22]=1>[Pd]>[CH2:1]([O:3][C:4]([C:6]1[C:11]([NH:16][C:17]2[CH:18]=[N:19][CH:20]=[N:21][CH:22]=2)=[CH:10][CH:9]=[C:8]([CH2:13][CH3:15])[N:7]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 344373Pyrimidin-5-amineHCID 69235471Ethyl 3-bromo-6-cyclopropyl-2-pyridinecarboxylate

Product 1

HCID 58368048HCID 58368048, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Palladium catalysed arylation of 3-Bromo-6-cyclopropyl-pyridine-2-carboxylic acid ethyl ester with 5-Aminopyrimidine according to the general procedure described in example 78 step 3 yielded the title compound as a white solid, MS (ISP): m/e=273.3 (M+H+).

Sources & evidence

ORD record
ord-b2ebd6fda760442dbc92bfbe949d0715
Source dataset
uspto-grants-2008_08
Patent number
US07414060B2

Reaction notes

Loading…