Ethyl bromopyruvate → Ethyl 2-(cyclohexylamino)-1,3-thiazole-4-carboxylate

HRID 2219670Notes

Reaction equation

HRID 2219670 reaction equation
[CH:1]1([NH:7][C:8]([NH2:10])=[S:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Br[CH2:12][C:13](=O)[C:14]([O:16][CH2:17][CH3:18])=[O:15]>C(O)C>[CH:1]1([NH:7][C:8]2[S:9][CH:12]=[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[N:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 66144Ethyl bromopyruvateHCID 1471603Cyclohexylthiourea

Product 1

HCID 15053542Ethyl 2-(cyclohexylamino)-1,3-thiazole-4-carboxylate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of 0.25 g (1.6 mmol) of N-cyclohexylthiourea in 2.5 mL of ethanol was added 0.31 g of ethyl bromopyruvate. The reaction was heated at reflux for 17 hr then evaporated to leave the title compound.

Workup

  1. temperatureThe reaction was heated
  2. temperatureat reflux for 17 hr
  3. customthen evaporated

Sources & evidence

ORD record
ord-1ece7cf5962542ee89cebc004f2801e4
Source dataset
uspto-grants-2008_08
Patent number
US07414067B2

Reaction notes

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