Phosphate → L-Leucine

HRID 2219769Notes

Reaction equation

HRID 2219769 reaction equation
N[C@H](C(NCC(NCC(N[C@H](C([NH:32][C@H:33]([C:38]([OH:40])=[O:39])[CH2:34][CH:35]([CH3:37])[CH3:36])=O)CC1C=CC=CC=1)=O)=O)=O)CC1C=CC(O)=CC=1.P([O-])([O-])([O-])=O>>[NH2:32][C@H:33]([C:38]([OH:40])=[O:39])[CH2:34][CH:35]([CH3:37])[CH3:36]

Participants

3

Reactant 2

HCID 1061PhosphateHCID 461776N-(N-(N-(N-L-Tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucine

Product 1

HCID 6106L-Leucine

Procedure

The degradation H-Tyr-Gly-Gly-Phe-Leu-OH (SEQ ID NO: 12) (˜1.8×10−4 M) in 50 MM phosphate buffer solutions of pH 7.4 containing carboxypeptidase A (1 U/ml) was studied as described above. The pseudo first-order rate constant for the degradation was estimated to 9.8×10−1 min−1 and the corresponding half-life calculated to 0.7 min as previously described.

Workup

  1. wait−1 and the corresponding half-life calculated to 0.7 min

Sources & evidence

ORD record
ord-1abf1ee2c5ed4728b0063d184b1aa5eb
Source dataset
uspto-grants-2008_08
Patent number
US07414107B2

Reaction notes

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