反应详情

To a flask, were added 6.6 g (50 mmol) of 4-aminobenzyl cyanide, 4.04 mL of pyridine and 100 mL MtBE. To this mixture, 10 g of p-menthane-3-carbon*yl chloride were added dropwise over 5 minutes. The reaction mixture was stirred for 24 h. To the reaction mixture, 50 mL of water were added. The mixture was separated. The organic layer was washed with 50 mL of water and 50 mL of brine. The organic layer was dried over MgSO4. The solvent was evaporated in vacuo to afford the crude product, which was recrystallized from hexanes to afford 10.1 g of the desired product with the following spectroscopic properties:

1. customThe mixture was separated
2. washThe organic layer was washed with 50 mL of water and 50 mL of brine
3. dry with materialThe organic layer was dried over MgSO4
4. customThe solvent was evaporated in vacuo
5. customto afford the crude product, which
6. customwas recrystallized from hexanes