HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → N'-(2-hydroxy-3-phenylpyrido[2,3-b]pyrazin-6-yl)nicotinohydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Nicotinic Acid | HCID 938 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | HCID 178514300 | HCID 178514300 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | N'-(2-hydroxy-3-phenylpyrido[2,3-b]pyrazin-6-yl)nicotinohydrazide | HCID 178523945 | — |
Reaction Steps
To a mixture of 6-hydrazino-3-phenylpyrido[2,3-b]pyrazin-2-ol (3-3) (3.7 g, 14.5 mmol) and nicotinic acid (2.1 g, 17.4 mmol) in NMP (50 mL) was added EDC (3.1 g, 16.0 mmol), and stirred at room temperature for overnight. To the mixture was added water, and the resulting solid was collected by filtration to yield N-(2-hydroxy-3-phenylpyrido[2,3-b]pyrazin-6-yl)nicotinohydrazide (3-4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08207169B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-2b5411ef05394b8583677cc249f58a3a |
| Source note | uspto-grants-2012_06 |