HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2219934Generated: November 5, 2026
2,3-Dichloropyridine → 7-(3-Chloropyridin-2-yl)-N-(4-(difluoromethoxy)phenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine
https://huagongshe.com/reaction/2219934
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2,3-Dichloropyridine | HCID 16988 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | N-(4-(Difluoromethoxy)phenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine | HCID 59021531 | — |
| Product | 7-(3-Chloropyridin-2-yl)-N-(4-(difluoromethoxy)phenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine | HCID 12004341 | — |
Reaction Steps
The title compound was prepared according to the procedure given for Example 9 using N-(4-(difluoromethoxy)phenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine (0.091 g, 0.31 mmol), 2,3-dichloropyridine (0.092 g, 0.62 mmol) and N,N-diisopropylethylamine (0.081 mL, 0.47 mmol) and heating the reaction mixture for 10 h at 170° C. to obtain 0.038 g of a light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07414131B2 |
|---|
| Source dataset | uspto-grants-2008_08 |
|---|
| ORD ID | ord-538f8174024a46488cbf00dff005a50b |
|---|
| Source note | uspto-grants-2008_08 |
|---|
