5,6,7,8-Tetrahydro-7-(phenylmethyl)pyrido(3,4-d)pyrimidin-4(3H)-one → 5,6,7,8-Tetrahydropyrido[3,4-D]pyrimidin-4(3H)-one

HRID 2219968Notes

Reaction equation

HRID 2219968 reaction equation
C([N:8]1[CH2:17][CH2:16][C:15]2[C:14](=[O:18])[NH:13][CH:12]=[N:11][C:10]=2[CH2:9]1)C1C=CC=CC=1>CO.[OH-].[Pd+2].[OH-]>[N:11]1[C:10]2[CH2:9][NH:8][CH2:17][CH2:16][C:15]=2[C:14](=[O:18])[NH:13][CH:12]=1

Participants

4

Reactant 1

HCID 1357235075,6,7,8-Tetrahydro-7-(phenylmethyl)pyrido(3,4-d)pyrimidin-4(3H)-one

Product 1

HCID 1357416015,6,7,8-Tetrahydropyrido[3,4-D]pyrimidin-4(3H)-oneYield 96%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one (1.5 g, 6.2 mmol) was dissolved in methanol (25 mL) and palladium hydroxide was added (1.5 g, 20% wt). The mixture was shaken on a Parr Shaker under H2(g) atmosphere (60 PSI) for 3 days. The mixture was filtered through celite and evaporated to give 0.9 g of material as a yellow solid (96%), which was used as such for the next step.

Workup

  1. filtrationThe mixture was filtered through celite
  2. customevaporated

Sources & evidence

ORD record
ord-6c5d17ba8ee44eb1944bc4db41d650d4
Source dataset
uspto-grants-2008_08
Patent number
US07414131B2

Reaction notes

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