反应详情

A mixture of 66.1 g (0.234 mol) of 2-Hydroxy-4-octyloxy benzoic acid methyl ester obtained in Step 1, 44.7 g (0.30 mol) of 5-Bromopent-1-ene, 207 g (1.5 mol) of K2CO3 and 700 mL of dry butanone is refluxed for 24 h, then allowed to return to room temperature. The reaction mixture is filtered and the butanone is distilled off under reduced pressure. After drying the residue under vacuum a slightly yellow oil (77.5 g, 95%) is obtained, which can be used in the next step without further purification.

1. temperatureis refluxed for 24 h
2. customto return to room temperature
3. filtrationThe reaction mixture is filtered
4. distillationthe butanone is distilled off under reduced pressure
5. dry with materialAfter drying the residue under vacuum a slightly yellow oil (77.5 g, 95%)
6. customis obtained
7. customwhich can be used in the next step without further purification