4-Methoxycyclohexanol (cis,trans) → 4-Methoxycyclohexanone

HRID 2220057Notes

Reaction equation

HRID 2220057 reaction equation
[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][CH:6]([OH:9])[CH2:5][CH2:4]1.[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1.[O-2].[Al+3].[O-2].[O-2].[Al+3]>ClCCl>[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]1

Participants

5

Reactant 3

HCID 1403324-Methoxycyclohexanol (cis,trans)HCID 9989226AluminaHCID 178418287HCID 178418287, compound

Product 1

HCID 5350284-Methoxycyclohexanone

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 4.2 g 4-methoxycyclohexanol in 30 ml dichloromethane is added to a suspension of 52.6 g pyridinium chlorochromate on basic aluminium oxide in 90 ml dichloromethane. The suspension is stirred for 3 h at ambient temperature. Then the mixture is filtered through silica gel (dichloromethane) and the solvent is eliminated.

Workup

  1. filtrationThen the mixture is filtered through silica gel (dichloromethane)

Sources & evidence

ORD record
ord-2d832d0e2c544a72aa0bb16ba7489bac
Source dataset
uspto-grants-2008_08
Patent number
US07417032B2

Reaction notes

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